1. Name : Asst. Prof. Dr.RUENGWIT KITBUNNADAJ

ผศ.ดร.เรืองวิทย์ กิจบรรณเดช

Academic Position : Assistant Professor
Department : Department of Pharmaceutical Chemisrty and Pharmacognosy
Phone : 0-5596-3717
e-mail : rkitbunna@hotmail.com

2. Contact Address

  • Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok THAILAND 65000

    3. Educational Background

    • 2004 : Ph.D (Pharmacochemistry) , Vrije Universiteit Amsterdam (VU), The Netherlands ,
    • 1996 : M.Sc. in Pharmacy (Medicinal Chemistry) , Chulalonkorn University , Thailand
    • 1993 : B.Pharm. (Bachelor of Pharmacy) , Chiangmai University , Thailand

    4. Field of Experties

    • Drug design
    • Medicinal Chemistry
    • Molecular Pharmacology
    • Organic Synthesis
    • Medicinal chemistry for doctor of pharmacy: Antibacterials, antimicrobials, histaminergic drugs, gastro-intestinal drugs, antiviral and anti-HIV, anticancer drugs, cholinergic and adrenergic drugs, hypoglycemic drugs, and diuretic drugs
    • Pharmaceutical quality control for doctor of pharmacy: Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry
    • Drug discovery and design
    • Drug action in pharmaceutical chemistry
    • Instrumental research techniques in pharmaceutical sciences for graduate students: Mass spectrometry (structure identification)

    5. Publication / Books

      5.01 Research Publication
    • Khorana, N. , Markmee, S. , Ingkaninan, K. , Ruchirawat, S. , Kitbunnadaj, R. , Pullagurla, M.R. . 2009 . Evaluation of a new lead for acetylcholinesterase inhibition . Medicinal Chemistry Research . 18 : 231-241.
    • Kitbunnadaj, R. , Hoffmann, M. , Ahmed el Jilali, , Fratantoni, S.A. , Bongers, G. , Bakker, R.A. , Wieland, K. , Iwan J. P. de Esch , Wiro M. P. B. Menge , Timmerman, H. , Lovenberg, T. , Leurs, R. . 2005 . New high affinity H3 receptor agonists without a basic side chain . Journal of Bioorganic & Medicinal Chemistry . 13 : 6309-6323.
    • Kitbunnadaj, R. , Hashimoto, T. , Poli, E. , Zuiderveld, O.P. , Menozzi, A. , Hidaka, R. , Iwan J. P. de Esch, , Bakker, R.A. , Wiro, M. . 2005 . Piperidinyl Alkyl Imidazoles: Discovery of Methimepip as a Novel, Potent and Selective Histamine H3 Receptor Agonist . Journal of Medicinal Chemistry . 48 : 2100-2107.
    • Poli, E. , Menozzi, A. , Pozzoli, C. , Coruzzi, G. , Kitbunnadaj, R. , Timmerman, H. , Leurs, R. . 2004 . Functional Characterization of the Novel Histamine H3 Receptor Agonist, VUF 5810, On the Guinea-pig Isolated Ileum. 53 (Supplement 1), S77–S78 . Inflammatory Research .
    • Kitbunnadaj, R. , Zuiderveld, O.P. , Christophe, B. , Hulscher, S. , Wiro M. P. B. Menge , Gelens, E. , Snip, E. , Bakker, R.A. , Celanire, S. , Gillard, M. , Talaga, P. , Timmerman, H. , Leurs, R. . 2004 . Identification of 4-(1H-Imidazol-4(5) ylmethyl)pyridine (Immethridine) As a Novel, Potent, and Highly Selective Histamine H3 Receptor Agonist . Journal of Medicinal Chemistry . 47 : 2414-2417.
    • Adami, M. , Coruzzi, G. , Guaita, E. , Schunack, W. , Kitbunnadaj, R. , Timmerman, H. . 2004 . Neuronal Histamine H3 Receptors Mediate Antisecretory Effects In the Rat Isolated Gastric Fundus, 53 (Supplement 1), S25–S26 . Inflammatory Research .
    • Kitbunnadaj, R. , Zuiderveld, O.P. , Iwan J. P. de Esch , Vollinga, R.C. , Bakker, R.A. , Lutz, M. , Spek, A.L. , Cavoy, E. , Deltent, M-F. , Wiro M. P. B. Menge, , Timmerman, H. , Leurs. R. . 2003 . Synthesis and Structure-Activity Relationships (SAR) of Conformationally Constrained Histamine H3 Receptor Agonists . Journal of Medicinal Chemistry . 46 : 5445-5457.
    • Hiranyaekaphap, T. , Srimongkolpithak, N. , Wongchang, T. , Poowaruttanawiwat, P. , Rattanamanee, K. , Kitbunnadaj, R. . 2556 . Discovery of novel cholinesterase inhibitor (RKNU026) with β-amyloid aggregation inhibitory activity. 38 (suppl.), 4-7 . The Thai Journal of Pharmaceutical Sciences .

      5.02 Academic Publication
    • Kitbunnadaj, R. . 2548 . Histamine receptors and their ligands. . Naresuan University Journal . 13 (3), หน้า 41-53.

      5.03 Proceeding
    • Hiranyaekaphap, T. , Srimongkolpithak, N. , Wongchang, T. , Poowaruttanawiwat, P. , Rattanamanee, K. , Kitbunnadaj, R. . . 2557. Discovery of novel cholinesterase inhibitor (RKNU026) with β-amyloid aggregation inhibitory activity, . Proceeding of the 30th Annual Research Conference in Pharmaceutical Sciences, 1 มกราคม 2557, Chulalongkorn University, Bangkok, Thailand.

      5.04 Poster | Oral Presentation
    • Markmee, S. , Ingkaninan, K. , Kitbunnadaj, R. , Ruchirawat, S. , and Khorana, N. . Synthesis of Isoquinoline Derivatives as Acetylcholinesterase Inhibitors, . The Fourth Indochina conference on Pharmaceutical Sciences” (PHARMA INDOCHINA IV), 1 มกราคม 2557 , University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
    • Richard M. van Rijn , Zuiderveld, O.P. , Kitbunnadaj, R. , Bakker, R.A. , Leurs, R. . [125I]Iodophenpropit as an Iodinated Histamine H4 Receptor Radioligand, . XXXII Annual Meeting of the European Histamine Research Society, 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Kitbunnadaj, R. , Zuiderveld, O.P. , Wiro M. P. B. Menge , Bakker, R.A. , Timmerman, H. , Leurs, R. . 4-[3-(1H-Imidazol-5-yl)propyl]piperidine (VUF5681) As Novel Selective Neutral Antagonist At the Human Histamine H3 Rece, . XXXII Annual Meeting of the European Histamine Research Society, , 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Bongers, G. , Deken, D. , Kitbunnadaj, R. , Bakker, R.A. , Leurs, R. . Species Differences for the Rat and Human Histamine H3 Receptor: Effect of Sodium Ions, . XXXII Annual Meeting of the European Histamine Research Society, , 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Adami, M. , Coruzzi, G. , Guaita, E. , Schunack, W. , Kitbunnadaj, R. , Timmerman, H. , Leurs, R. . Neuronal Histamine H3 Receptors Mediate Antisecretory Effects In the Rat Isolated Gastric Fundus, . XXXII Annual Meeting of the European Histamine Research Society, , 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Poli, E. , Menozzi, A. , Pozzoli, C. , Coruzzi, G. , Kitbunnadaj, R. , Timmerman, H. , Leurs, R. . Funtional Characterisation of the Novel Histamine H3 Receptor Agonist, VUF 5810, On the Guinea-pig Isolated Ileum, . XXXII Annual Meeting of the European Histamine Research Society, , 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Kitbunnadaj, R. , Zuiderveld, O.P. , Wiro M. P. B. Menge , Bakker, R.A. , Hashimoto, T. , Yamatodani, A. , Adami, M. , Coruzzi, G. , Timmerman, H. , Leurs, R. . N-Substituted Piperidinyl Alkyl Imidazoles: Discovery of a Potent and Highly Selective Histamine H3 Receptor Agonist, . XXXII Annual Meeting of the European Histamine Research Society, , 1 มกราคม 2557 , Noordwijkerhout, the Netherlands.
    • Kitbunnadaj, R. , Zuiderveld, O.P. , Jongejan, A. , Wiro M. P. B. Menge , Timmerman, H. , Leurs, R. . Synthesis, and Structure-Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists, . XVII International Symposium on Medicinal Chemistry, 1 มกราคม 2557 , Barcelona, Spain..
    • Patarapanich, C. , Saisorn, B. , Kitbunnadaj, R. . Synthesis of O-alkyl, or O-aryl derivatives of 2-propylpentanohydroxamic Acid, . XIII Symposium on Pharmaceutical Sciences Research, 1 มกราคม 2557 , Chulalongkorn University, Bangkok, Thailand.

      5.05 Patent | Petty Patent
    • . Submitted: 1,4-ไดเอราคิลพิเพอราซีน (1,4-diaralkylpiperazine) ที่มีฤทธิ์ยับยั้งการทำงานของ เอนไซม์โคลีนเอสเทอเรส (cholinesterase) (เลขที่คำขอ 1403000676) .
    • . Submitted: 2-ออกโซ-2ไฮโดรเจน-โครเมน-7-อิลคาร์บาเมต (2-oxo-2H-chromen-7-yl carbamate) ที่มีฤทธิ์ยับยั้งการทำงานของเอนไซม์โคลีนเอสเทอเรส (cholinesterase) (เลขที่คำขอ 1303000830) .
    • . Submitted: 7-อะมิโนแอลคิล-2ไฮโดรเจน-โครเมน-2-โอน (7-aminoalkyloxy-2H-chromen-2one) ที่มีฤทธิ์ยับยั้งการทำงานของเอนไซม์โคลีนเอสเทอเรส (cholinesterase) (เลขที่คำขอ 1303000829) .
    • . Submitted: อนุพันธ์ของ 2,6-ไดคลอโร-เอ็น-ฟีนิลอะนิลีน(2,6-dichloro-N-phenylaniline) ที่มีฤทธิ์ยับยั้งการทำงานของเอนไซม์ไซโคลออกซิจิเนส (cyclooxygenase) (เลขที่คำขอ 1303000744) .

      5.09 Book-ทั้งเล่ม
    • Kitbunnadaj, R. . 2559 . Handbook for Graduate Students. Instrumental Research Techniques in Pharmaceutical Sciences for Graduate Students: Mass Spectrometry (Structure Identification) , Phitsanulok. Thailand..
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Antibacterial and Antimicrobial Agents , Phitsanulok. Thailand. .
    • Ruengwit Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Anticancer Drugs , Phitsanulok. Thailand..
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Antihistamines and Gastro-intestinal Drugs , Phitsanulok. Thailand. .
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Antivirals and Anti-HIV Drugs , Phitsanulok. Thailand.
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Diuretic Drugs , Phitsanulok. Thailand.
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Hypoglycemic Drugs , Phitsanulok. Thailand. .
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Medicinal Chemistry for Doctor of Pharmacy: Peripheral Nervous System (PNS) Drugs , Phitsanulok. Thailand.
    • Kitbunnadaj, R. . 2559 . Handbook for Pharmacy Students. Pharmaceutical Quality Control for Doctor of Pharmacy: Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry , Phitsanulok. Thailand..

    7. Ongoing Research

    • Development of potent compounds as novel drug candidates in various areas
    • Action mechanism of drugs through their targeted proteins (receptors and enzymes)
    • Design synthesis and pharmacological evaluation of novel acetylcholinesterase inhibitors
    • Design synthesis and pharmacological evaluation of novel selective cyclooxygenase-2 inhibitors

    8. Awards

    • 2016 : รองชนะเลิศอันดับ 2 สาขาวิทยาศาสตร์ งานประกวดโครงการรางวัลนวัตกรรมแห่งประเทศไทย ครั้งที่ 8 , กระทรวงวิทยาศาสตร์และเทคโนโลยี สมาคมวิทยาศาสตร์แห่งประเทศไทย
    • 2008 : รางวัลชนะเลิศ โครงงานวิจัยและข้อเสนองานวิจัยนักวิทยาศาสตร์รุ่นเยาว์ ครั้งที่ 1 (2551) (CGI Award for Young Scientists 2008) , สถาบันบัณฑิตศึกษาจุฬาภรณ์และสถาบันวิจัยจุฬาภรณ์ (อาจารย์ที่ปรึกษาโครงงานวิจัย)



  • Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand