1. Name : Asst. Prof. Dr.Dumrongsak Pekthong

ผศ.ดร.ดำรงศักดิ์ เป๊กทอง

Academic Position : Assistant Professor (พนักงานมหาวิทยาลัย-พนักงานวิชาการ)
Department : Department of Pharmacy Practice
Phone : 0 5596 1833
e-mail : dumrongsakp@yahoo.com, dumrongsak029@gmail.com

Administrative Position

  • Assistant to the President , Faculty of Pharmaceutical Sciences , Naresuan University

2. Contact Address

  • Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok THAILAND 65000

    3. Educational Background

    • 2012 : Post doctotal (Pharmacology and Toxicology) , Université de Strasbourg (UdS) , France
    • 2008 : Ph.D. (Pharmacology) , Universite de Franche-Comte , France
    • 2000 : M.Sc. (Pharmacology) , Mahidol University , Thailand
    • 1995 : B.Pharm. (Bachelor of Pharmacy) , Chiangmai University , Thailand

    4. Field of Experties

    • Xenobiotic Metabolizing Enzymes (XMEs)
    • In vitro Prediction of Drug Interaction and Hepatotoxicity
    • Drug-Induced Liver Injury
    • Analytical Chemistry
    • Molecular Cell Biology
    • Separation and Analytical Chemistry

    5. Publication / Books

      5.01 Research Publication
    • 2015 . [6]-Gingerol inhibits de novo fatty acid synthesis and carnitine palmitoyltransferase-1 activity which triggers apoptosis in HepG2. . Am J Cancer Res. (5) : 1319-1336.
    • 2015 . Prediction of drug induced liver injury using molecular and biological descriptors. . Comb Chem High Throughput Screen (18) : 315-322.
    • Impheng, H. , Pongcharoen, S. , Richert, L. , Pekthong, D, , Srisawang, P. . 2014 . The Selective Target of Capsaicin on FASN Expression and De Novo Fatty Acid Synthesis Mediated through ROS Generation Triggers Apoptosis in HepG2 Cells . PLOS ONE . 9 : 1-17.
    • Alexandre, E. , Baze, A. , Parmentier, C. , Desbans, C. , Pekthong, D. , Gerin, B. , Wack, C, , Bachellier, P. , Heyd, B. , Weber, J.C. , Richert, L. . 2012 . Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers. . Xenobiotica . 42 : 968-979.
    • Pekthong, D. , Desbans, C. , Martin, H. , Richert, L. . 2012 . Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity . Drug Metabolism and Disposition . 40 : 32-38.
    • Abadie, C. , Martin, H, , Blanchard, N. , Alexandre, E. , Pekthong, D. , Bachellier, P. , Mantion, G. , Heyd, B. , Richert, L. . 2010 . Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions . Toxicology in Vitro . 24 : 346-356.
    • Richert, L. , Tuschl, G. , Abadie, C. , Blanchard, N. , Pekthong, D. , Mantion, G. , Weber, J.C. , Mueller, S.O. . 2009 . Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes . Toxicology and Applied Pharmacology . 235 : 86-96.
    • Pekthong, D. , Blanchard, N. , Abadie, C. , Bonet, A. , Heyd, B. , Mantion, G. , Berthelot, A. , Richert, L. , Martin, H. . 2009 . Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures . Chemico-Biological Interactions . 179 : 247-255.
    • Pekthong, D. , Martin, H. , Abadie, C. , Bonet, A. , Heyd, B. , Mantion, G. , Richert, L. . 2008 . Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide . Journal of Ethnopharmacology . 115 : 432-440.
    • Jeenapongsa, R. , Pekthong, D. , Thippayawan, T. , Choorassamee, J. , Buathong, J. , Sommanus, R. , Wannapun, J. , Sangamnatdej, S. . 2004 . Glibenclamide and a Thai herbal medicine (Momordica charantia) powder increase HNF-1alpha gene transcription.(Suppl. A) . Drugs of the Future . 29 : 238--.

      5.03 Proceeding
    • . 2010. Bupropion Hydroxylation as a Selective Marker of Rat Cytochrome P450 2B1 Catalytic Aactivity, . ISSX 9TH International Meeting Istanbul, TURKEY 2010, , 4 - 8 September 2010.
    • . 2009. Plantasafe Asian Plant -Derived drugs and hepatic safety:Studies to improve research transfer to application in patients, . 2 nd France Bio-Asia Conference, Keelung, TAIWAN , 25 - 28 November 2009.
    • . 2008. Optimization and downscaling of hepatocyte culture conditions for screening of compounds, . 10th European Meeting of International Society for the study of Xenobiotics (ISSX), Vienna, AUSTRIA , 18 - 21 May 2008.
    • . 2008. 0ptimisation of culture and treatment conditions of rat and human hepatocytes for CYP450 expression and inducibility, . 10th European Meeting of International Society for the study of Xenobiotics (ISSX), Vienna, AUSTRIA , 18 - 21 May 2008.
    • . 2008. Effects of Andrographis paniculata extract and Andrographolide on hepatic CYP450 mRNA expression and monooxygenase act., . 7th Joint Meeting of AFERP, ASP, GA, PSE & SIF, Athens, GREECE , 3 - 8 August 2008.
    • . 2555. Bacopa monnieri extract affects major cytochrome P450 mRNA expression and monooxygenase activities in human hepatocyte c, . 34th Annual Meeting of The Pharmacological and Therapeutic Society of Thailand, 22 - 24 มีนาคม 2555.

      5.04 Poster | Oral Presentation
    • Pekthong, D. , Ingkaninan, K. , Gromand, J. , Heyd, B. , Weber, J.C. , Richert, L. , Martin, H. . Bacopa monnieri extract affects major cytochrome P450 mRNA expression and monooxygenase activities in human hepatocyte cultures. , . Poster presentation at 34th Annual Meeting of The Pharmacological and Therapeutic Society of Thailand, 22 - 24 มีนาคม 2555 , Bangkok, Thailand.
    • Martin, H. , Pekthong, D. , Ingkaninan, K. , Richert, L. . Effect of Bacopa extract on CYP activity and CYP expression in rat hepatocyte cultures, . Oral presentation at Bio-Asia Project: PLANTASAFE-2nd seminar-From Pharmacognosy to Pharmacology: Integrative approach of natural product research, 22 - 24 มีนาคม 2555 , Phitsanulok, Thailand.
    • Pekthong, D. , Bonet, A. , Desbans, C. , Richert, L. , Martin, H. . Bupropion Hydroxylation as a selective marker of rat Cytochrome P450 2B1 catalytic activity, . Poster presentation at 9th International Meeting of International Society for the study of Xenobiotics (ISSX), 22 - 24 มีนาคม 2555 , Istanbul, Turkey.
    • Alexandre, E. , Pekthong, D. , Baze, A. , Parmentier, C. , Bachellier, P. , Mantion, G. , Heyd, B. , Hewitt, N. , Richert, L. . Cryopreserved human hepatocytes for the prediction of metabolic clearance and drug-drug interactions in humans, an update, . Oral presentation at 3rd Asian Pacific Regional Meeting, 22 - 24 มีนาคม 2555 , Bangkok, Thailand.
    • Pekthong, D. , Blanchard, N. , Abadie, C. , Bonet, A. , Heyd, B. , Mantion, G. , Berthelot, A. , Richert, L. , Martin, H. . Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities, . cytochrome P450 mRNA expression and monooxygenase activities. 7th Joint Meeting of AFERP, ASP, GA, PSE & SIF, 22 - 24 มีนาคม 2555 , Athens, Greece .
    • Abadie, C. , Martin, H. , Blanchard, N. , Pekthong, D. , Heyd, B. , Mantion, G. , Weber, J.C. , Schuler, F. , Coassolo, P. , Richert, L. . Optimisation of culture and treatment conditions of rat and human hepatocytes for cytochrome P450 expression and inducibility, . Poster presentation at 10th European Meeting of International Society for the study of Xenobiotics (ISSX), 22 - 24 มีนาคม 2555 , Vienna, Austria.
    • Dominguez, L. , Abadie, C. , Sagorny, K. , Guenzi, J.P. , Pekthong, D. , Heyd, B. , Mantion, G. , Alexandre, E. , Blanchard, N. , Richert, L. . Optimization and downscaling of hepatocyte culture conditions for screening of compounds, . Poster presentation at 10th European Meeting of International Society for the study of Xenobiotics (ISSX),, 22 - 24 มีนาคม 2555 , Vienna, Austria.

    7. Ongoing Research

    • In Vitro Prediction of Herb-Drug Interactions
    • Isolation, purification and structure elucidation of bioactive compounds of Actinobacteria from forest soil of Nam Nao national park in Thailand
    • Preparation and evaluation of in vitro 3D culture of human hepatocytes as a model for application in drug-induced hepatotoxic screening
    • Cancer Chemopreventive Properties of Thai Fruits
    • Use primary hepatocytes system as an in vitro model for studying Drug-Induced Liver Injury (DILI)
    • 3D human hepatocytes culture
    • An in vitro, herb-drug interaction study of Thai herbal medicine: Inhibition potential on drug-metabolizing enzymes
    • In vitro techniques and bioinformatics for Drug-Induced Liver Injury prediction

    10. Training

    • 12 - 16 พฤศจิกายน 2555 , Secondary Metabolites; From Extraction to Structure elucidation , มหาวิทยาลัยเกษตรศาสตร์, บางเขน, กรุงเทพฯ , Thailand
    • 14 - 16 September 2011 , 3rd Annual Predictive Toxicology , Berlin , Germany
    • 10 - 12 พฤษภาคม 2552 , The 3rd Asian Pacific Regional ISSX Meeting , The Imperial Queen's Park Hotel, Bangkok , Thailand
    • 18 - 20 มีนาคม 2552 , The 31th Pharmacological and Therapeutic Society of Thailand Meeting , ขอนแก่น , Thailand



  • Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand